Pain, Pain, Go Away!

USA Today reports that study subjects lost dramatic amounts of weight with diabetes drug tirzepatide. Participants in the randomized, controlled trial lost an average of 15% of their weight at week 72 according to an article in the New England Journal of Medicine .  Photo by  Sara Bakhshi  on  Unsplash How does it work? USA Today's interview with a participant offers a clue: The drug prevented her from overeating, [participant Mary] Bruehl said.  If she overindulged, the food would come back up. "I've learned to stop before I get that feeling," she said...The one negative side effect was nausea, which Bruehl felt the day after each of her weekly shots of tirzepatide. She's not alone. From the study , The most common adverse events with tirzepatide were gastrointestinal, and most were mild to moderate in severity, occurring primarily during dose escalation. Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving ...

It looks like Reason magazine has been reading about my diet...or maybe just studies showing no associations between red meat and mortality, saturated fat and heart disease, stroke or cardiovascular disease, or salt consumption and disease. Summarizing published research from the past few years, the article calls the government's dietary advice of the past forty years a fiasco of misinformation,  even noting there's a positive association between a low-sodium diet and death. It adds that the US government's Dietary Guidelines Advisory Committee has dropped their long crusade against cholesterol. The article explains, Observational studies [which the government relied on] may be good at developing hypotheses, but they are mostly not a good basis for making behavioral recommendations and imposing regulations. It's refreshing for the mainstream media to recognize that mainstream dietary advice hasn't been working instead of parroting the same misinformation. T...

A "sensible diet" must be the one of the hardest things to figure out, even for a sensible person. There's always been conflicting advice, but with medical studies in respected journals being retracted and authorities admitting they were wrong about fat, and various laymen flip-flopping on dietary advice, we're living in confusing times. This post is to help readers sort it out for themselves. First, what is "sensible," or more to the point, what is the truth? I think it's something that meets one or more of these criteria: Something observable, directly or indirectly Something that stands up to scrutiny (i.e., it's not a trick) Something that fits with everything else you know Something that can be used to reliably predict other things Note that something sensible or truthful isn't necessarily balanced, it doesn't matter who does or doesn't believe in it, or how long it's been around. It's independent of all those t...

I normally gather information, analyze things and take measurements. Lately, though, things have been too hectic to go about life like a monk: a deadline at work and family issues that have been...bizarre. Let me know if you need material for a black comedy. I've been eating on instinct, and instinct has led me to eating more protein and probably fewer calories than normal: mostly black coffee, diet Dr. Pepper (caffeine soothes me), bunless burgers, a little veg, a few egg rolls (they're comfort food), and a lot of Atkins bars. No fatty sauces--they just haven't sounded good, especially in the morning. Result: I'm down two belt holes on my rain coat from a few months ago and my shoes are slightly loose where they used to hurt my feet from being too tight. Atkins induction made me feel weird for a while, and Body-for-Life made me feel great (in the beginning). BFL is much higher-protein than Atkins induction. I noticed back in my 20s that I felt a lot better when I ...

Over the years, I've read some strange ideas about what the Atkins diet is: All meat A crash diet Not low-carb, high fat High protein An eating plan where you gorge yourself Wrong on all counts. A friend of mine was curious a few weeks ago about what it really was. I described it to her, and she can't stop raving about it now: Friend: What do you eat? Me: Meat, eggs, cheese, non-starchy vegetables, and fats like olive oil, mayonnaise, lard and butter. Friend: How much do you eat? Me: You eat until you're full. Friend: When do you eat? Me: Whenever you're hungry. You should also take some vitamins. There are more details, of course, but that's it in a nutshell. How does such a simple diet get so convoluted in people's minds? I blame fads in eating and thought. A trend now is to eat vegetables by the pound --no exaggeration. Dr. Atkins' Diet Revolution specifically says not to fill yourself with vegetables--that's a tactic of tradi...

I feel well enough to try Atkins induction again. The palpitations are gone, even without taking potassium. My energy level is back to normal--no more trucking on the treadmill early in the morning  to burn off nervous energy or emergency meat, cheese and mineral water stops after yoga. It's back to lounging around to Chopin and Debussy in the morning and stopping at the wine bar for pleasure. I'm using the original Atkins book: Dr. Atkins' Diet Revolution from 1972. While looking in the book for a way to make gelatin (which is allowed on induction, but Jello(TM) and products like it have questionable ingredients), I felt the earth move under my feet : those recipes from 42 years ago look delicious and they're mostly real food. It makes sense, though: the cooks who wrote the recipes probably didn't have had a palette used to low-fat food full of added sugar or a bag of tricks to make low-fat food edible. Anyone who writes a recipe called "Cottage Cheese and...

It's going both well and badly. My mouth is healing. It stopped bleeding after a day and the chunk my surgeon removed from the roof of my mouth (the size felt somewhere between a shotgun pellet and a pea) feels like it's mostly grown back. Both sites are still tender, though. I'm talking better; I could barely stand to move my mouth for a few days. And I'm down 4.1 pounds since I started Atkins induction a few days ago. But I spent an uncomfortable day today: my heart was pounding even though I was sitting at my desk having a slow day at work among pleasant coworkers. I popped potassium pills to little avail. My distress could have a few causes: Very low carb diet, which has given me palpitations before. Low blood pressure. Right before surgery--when I was about to have my mouth cut and sewn, and I needed a potassium pill to chill out--it was 97/60. Bleeding for a day and relaxing would have only lowered this number. Low blood sugar. I haven't taken my b...

Last time I wrote about getting jittery and having a rapid heartbeat on VLC (very low carb). I cut way back on nuts a few weeks ago and felt remarkably better: more energy, and I can tell I lost a little weight because of the way my shoes and watchband fit. As I mentioned, taking a potassium pill helps the jitters and rapid heartbeat, and if it gets really bad, I can just eat a candy bar (we don't have safe starches at work). So for the first time, I tried Atkins induction. Why Atkins induction? It started with shorts. I'd been shopping for shorts and everything was very short (think Officer Jim Dangle on Reno 911 ), wildly patterned, ridiculous (where do you wear lace shorts if you're not starring in a Korean drama?) or knee length. There was even a high-waisted, pleated, acid washed pair from circa 1985. So when I saw a gray pair with sailor pant buttons, I bought them--even though they were pretty short (but not tight). Think Officer Dangle again. Being conscious of wea...

Hope you're having a Merry Christmas! It's the fourth anniversary of this blog and it's been almost that long since I started a low-carb diet and never looked back. That's not to say I never have a moment of weakness. Too much chocolate last week brought back the GI problems that I set out to solve four years ago. I can't eat chocolate bars in moderation, so I don't keep them around anymore. For others, it's Christmas cookies, stuffing, bread, pie, and other carbs that make this the most fattening time of the year. How to get back on track--or start a LC diet? Someone asked me this just yesterday. Since different approaches work for different people, here are a few sources for various types of people. Just tell me what to eat. Here's a quick guide to low-carb from Dr. Andreas Eenfeld t. I want to know how this actually works. Drs. Michael and Mary Dan Eades, who have treated thousands of patients with low-carb diets, explain diet, hormones and...

Yekra Player Yekra is a revolutionary new distribution network for feature films. Cereal Killers * * * * * The film follows Donal – a lean, fit, seemingly healthy 41 year old man – on a quest to hack his genes and drop dead healthy by avoiding the heart disease and diabetes that has afflicted his family. Donal’s father Kevin, an Irish gaelic football star from the 1960s, won the first of 2 All Ireland Championships with the Down Senior Football Team in 1960 before the biggest crowd (94,000) ever seen at an Irish sporting event. When Kevin suffered a heart attack later in life, family and friends were shocked. How does a lean, fit and seemingly healthy man – who has sailed through cardiac stress tests – suddenly fall victim to heart disease? Can a controversial diet consisting of 70% fat provide the answers? Losing weight, improving lipids and eliminating inflammation on a high-fat, low-carb diet? Yes--even if you have the genes for inflammation and heart dise...

You know the feeling: there's a system out there that's wildly popular, almost everybody uses it (except for some maverick non-fiction-loving nerds), and its proponents are at the top of the heap in their field. And yet the system isn't working for you. There's bloating. The help from on high isn't helpful. It takes so long to accomplish anything. It isn't you, it's the operating system. Low-fat diets are like Microsoft products: they're everywhere, and they work well enough for some people, but for others, they're an epic fail. Over the past few days, to work around an issue that Microsoft has known about for years and years, I've had to manually resize dozens of images every time I opened a document. And I've spent the entire evening tonight figuring out why my computer was at a standstill. (It turned out the automatic updates feature in good ol' Microsoft has been running up my CPU usage to 100%, bloating it like five servings o...

Regular Janes and Joes who watched the TV program Catalyst: Heart of the Matter on saturated fat, cholesterol and heart disease are probably confused now. What is this idea that saturated fat is good for you and that sugar and inflammation may cause heart disease? Everybody knows that saturated fat and cholesterol are bad, right? Regular Janes and Joes don't need to be doctors or scientists to consider some of the evidence for themselves. Or in this case, the lack of evidence. For forty years, and using hundreds of thousands of people, researchers have been trying to prove that saturated fat and cholesterol cause heart disease. The result, according to Dr. Robert Grenfell of the National Heart Foundation of Australia: When you ask that question of 'Do dietary fats increase heart disease?', you're sort of trying to negate all the other risk factors that, in fact, actually also cause heart disease. So, to imagine creating a study that would prove that conclusivel...

"Out with the old spiritual mumbo jumbo, the superstitions, and the backward ways. We're gonna see a brave new world where they run everybody a wire and hook us all up to a grid. Yes, sir, a veritable age of reason." -Ulysses McGill, O Brother, Where Art Thou? If only. Eighty years after the Tennessee Valley was put on the grid, health gurus recommend mumbo-jumbo like two-thirds of a cup of sugar a day for diabetics ,* inflammatory foods like wheat for the inflamed , and a low-fat, high-fiber, grain-based diet that fattens up livestock (in weeks!)** but is supposed to make humans slim and trim. The crazies are running the asylum. Are there any reasonable people in the mainstream? I recently sent a friend of mine the book It Starts with Food. It discusses the major hormones involved in fat storage, fat burning and inflammation, along with the authors' dietary recommendations based mostly on our paleolithic ancestors' diets and their clinical experience....

Everyone loves a good mystery, but in real life, we all love a good solution even more. The book Why Isn't my Brain Working? by Datis Kharrazian is the latter. Even if your brain is working (and I think mine works pretty well), it's worth reading for the insights into the gut-brain connection, cross-reactivity of foods, and what you can do if you get glutened. In my younger days, I read self-help books and went to counseling to be happier. It didn't help much--all they talked about was attitude. Relying on attitude to solve a biological problem is like trying to smile your way out of an infection of H. pylori. I guess I was lucky that I didn't go in for drugs and didn't think doctors could help me. Good thing. I now know my problem was largely hypoglycemia. The management of [certain patients with poor blood sugar control] is so fundamentally basic and easy....[Yet] It is not uncommon for [them] to be put on psychotropic drugs, sleep medications, or labeled ...

If I'm ever in a trench defending my homeland from barbarians, I want Linda Wells, Editor-in-Chief of Allure magazine, next to me. She's spent her last couple of vacations at a boot camp eating vegan food, sans booze, caffeine, gluten and sugar and going on five-hour hikes, getting blisters along the way. She doesn't feel (or sound) self-righteous. She's lost eight pounds, but says she's ready to "re-tox." The same issue of the magazine describes the program of a weight loss clinic called Medi-Weightloss: 500 to 800 calories a day of protein (around 125g to 200g), supplements, laxatives, and a prescription appetite suppressant called phendimetrazine. Jesus wept. Starvation diets--and this diet is well into starvation territory--have been well studied. They're known to cause weakness, fatigue, loss of libido and psychosis . Low-fat diets can cause depression, among other problems . And what's with the heaping helping of protein? Plugging in th...

There's a lot of conflicting dietary advice around, but conventional wisdom contradicts itself on diet for a healthy heart v. diet for healthy teeth. The commonly recommended heart-healthy diet is low-fat, little meat, lots of whole grains, and fruits and vegetables. That doesn't quite square with "Foods and Drinks Best for Your Teeth" from that pillar of medical dogma, WebMD.com: The best food choices for the health of your mouth include cheeses, chicken or other meats, nuts, and milk. These foods are thought to protect tooth enamel by providing the calcium and phosphorus needed to remineralize teeth (a natural process by which minerals are redeposited in tooth enamel after being removed by acids). Other food choices include firm/crunchy fruits (for example, apples and pears) and vegetables. These foods have a high water content, which dilutes the effects of the sugars they contain, and stimulate the flow of saliva (which helps protect against deca...

Anthropology professor Brian Fagan on diets of human ancestors: The Neanderthals were expert hunters, but when did hunting begin? Once again, the answer lies in Africa. Homo ergaster [a human ancestor from two million years ago] was an omnivore, completely accustomed to quite drastic environmental changes in the distribution of open grassland, forest, and semiarid terrain and the dietary shifts that went with them. Unlike their predecessors, these people were serious hunters and meat eaters--because they dwelled for the most part in open country, where meat was the dominant, though not, of course, only food source. We know this because the bones of numerous large mammals appear alongside stone butchering tools in some of the archeological sites that document their wanderings, whereas none appear in sites that predate them. .... Brain size is largest among species that hunt large mammals opportunistically while cooperating with and depending on one another. Brain size also correl...

It's day 2 of being back on a very low-carb diet. I'm off the sweet potatoes (you know, those wonderful safe starches) and I've cut back the dark chocolate. I thought it would take a couple of weeks to keto-adapt and get back to feeling good, but I'm already feeling like my old self: no more upset stomach, no dragging myself out of bed late this morning, no nap on the bus tonight, and no mid-afternoon grogginess. And no more humiliating thought that Alice Cooper , who started his band before I was born, could probably run circles around me. Blogger Kia Robertson could use some shame. She's the activist who made a useful idiot of her nine-year-old daughter at a McDonald's shareholders meeting. Mrs. Robertson, through her spokeschild, whined about McDonald's food and marketing. I doubt the Robertsons are shareholders in McDonald's. Call me a traditionalist, but a shareholders meeting is for shareholders, particularly grown-up ones who understand the b...

Dark chocolate and sweet potato fries are taking up too much of my diet--so much that I probably got up to about 70g of carb a day. That's probably too much carb to make ketones and too little glucose to feel energetic. Walk down the middle of the road, Margaret Thatcher said, and you get hit by the traffic from both sides. This might be the reason I've been tired and my stomach is upset so often these days. (Upper GI problems were the original reason I started a low-carb diet.) I overslept by an hour this morning after forgetting to reset my alarm, even after nine hours' sleep and my dog trying to get me up. My dog is going on a stricter diet, too, since she's up to 70 pounds. She eats low-carb home cooking, but needs to eat less of it. Bye-bye, balanced diet. I'm going to use pork rinds and emulsion sauce* instead of sweet potato fries as a vehicle for fat and salt. And no more denial about my chocolate habit. I was good today--I had about 30g of carb--and ...

Much more endnoting is needed! -Cindy Hoffman, one of my high school English teachers It's a shame that vegan activist Dr. Neal Barnard didn't learn English composition from Mrs. Hoffman: maybe we could see where he got the numerous pro-vegetarian quotes from paleoanthropologist Richard Leakey--enough to fill half a chapter in The Power of Your Plate . Leakey, according to Barnard, says that hunting in modern times isn't very important except as a macho male thing (page 175), that meat accounted for a small part of the diet on the African savannah (page 174), that the "excess of meat" from domesticated livestock is unusual (page 174), and that we wouldn't have had the teeth to deal with tearing flesh and hide (page 171). These statements are attributed to the same Richard Leakey who said, just two years before The Power of Your Plate came out in 1995, The expansion [of diet] involved making meat an important food source, not just an occasional items...