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Massive Weight Loss with Nauseating New Drug

USA Today reports that study subjects lost dramatic amounts of weight with diabetes drug tirzepatide. Participants in the randomized, controlled trial lost an average of 15% of their weight at week 72 according to an article in the New England Journal of Medicine .  Photo by  Sara Bakhshi  on  Unsplash How does it work? USA Today's interview with a participant offers a clue: The drug prevented her from overeating, [participant Mary] Bruehl said.  If she overindulged, the food would come back up. "I've learned to stop before I get that feeling," she said...The one negative side effect was nausea, which Bruehl felt the day after each of her weekly shots of tirzepatide. She's not alone. From the study , The most common adverse events with tirzepatide were gastrointestinal, and most were mild to moderate in severity, occurring primarily during dose escalation. Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-

Feeling Good on Higher Protein

I normally gather information, analyze things and take measurements. Lately, though, things have been too hectic to go about life like a monk: a deadline at work and family issues that have been...bizarre. Let me know if you need material for a black comedy. I've been eating on instinct, and instinct has led me to eating more protein and probably fewer calories than normal: mostly black coffee, diet Dr. Pepper (caffeine soothes me), bunless burgers, a little veg, a few egg rolls (they're comfort food), and a lot of Atkins bars. No fatty sauces--they just haven't sounded good, especially in the morning. Result: I'm down two belt holes on my rain coat from a few months ago and my shoes are slightly loose where they used to hurt my feet from being too tight. Atkins induction made me feel weird for a while, and Body-for-Life made me feel great (in the beginning). BFL is much higher-protein than Atkins induction. I noticed back in my 20s that I felt a lot better when I

Troubleshooting Low Energy, Low Mood & Other Problems on Atkins Induction

Do Calories Matter on Atkins? As the saying goes, just because you're not counting calories doesn't mean that calories don't count. Dr. Atkins wrote in Dr. Atkins' Diet Revolution that you'll lose weight faster on fewer calories, but you won't necessarily have a sense of well-being. Most readers knows what he means: low mood and flagging energy. Lack of Energy, Low Mood This was how I felt Sunday afternoon and Monday. Part of my low mood was from having to fill out an application for Medicaid for both my parents, mostly so that my father can go live in a nursing home. It's too hard for my mother to take care of him and I can't be with them enough to help day-to-day. I was thinking about my parents during yoga that evening and fighting tears. I didn't have a physical sense of well-being, either. The climb from the train station up to the street took more energy than it should have; so did the yoga class. I went back to the book for advice and r

It Doesn't Have to Be This Hard

If I'm ever in a trench defending my homeland from barbarians, I want Linda Wells, Editor-in-Chief of Allure magazine, next to me. She's spent her last couple of vacations at a boot camp eating vegan food, sans booze, caffeine, gluten and sugar and going on five-hour hikes, getting blisters along the way. She doesn't feel (or sound) self-righteous. She's lost eight pounds, but says she's ready to "re-tox." The same issue of the magazine describes the program of a weight loss clinic called Medi-Weightloss: 500 to 800 calories a day of protein (around 125g to 200g), supplements, laxatives, and a prescription appetite suppressant called phendimetrazine. Jesus wept. Starvation diets--and this diet is well into starvation territory--have been well studied. They're known to cause weakness, fatigue, loss of libido and psychosis . Low-fat diets can cause depression, among other problems . And what's with the heaping helping of protein? Plugging in th

Thanksgiving Stupor: It's Not the Turkey OR the Fat

An article on the Mental Floss magazine website blamed the stupor people usually feel after a Thanksgiving meal on (what else besides turkey?) the fat--229 grams of it in an "average Thanksgiving meal," according to the article. The urge to snooze is more the fault of the average Thanksgiving meal and all the food and booze that go with it. Here are a few things that play into the nap factor: Fats — That turkey skin is delicious, but fats take a lot of energy to digest, so the body redirects blood to the digestive system. Reduced blood flow in the rest of the body means reduced energy.  My response: Say what? First of all, even if you ate all the skin from half a turkey plus a whole stick of butter, that would be only 190 g of fat. (source: nutritiondata.com ) Thanksgiving is mostly a carbohydrate fest: potatoes, yams, desserts and most snack foods are mainly sugar and starch. Second, I'd like to see the evidence that a high-fat meal "reduces blood flow

This Just In: Kids Hate Diet Lunches

The Geneva Convention prohibits the killing of our taste buds. -Hawkeye Pierce, M*A*S*H School lunches have never been known for being appetizing, but under the new Healthy, Hunger-Free Kids Act, they're so bad that students are organizing protests. Some critics of the protests say that an 850-calorie limit should be enough, and if the kids don't like it, they should bring their own lunches. First, the calories. They're poor quality sugar and starch that's like Chinese food without the flavor and texture: it leaves you hungry an hour later--or a minute later for some kids. Google school lunch images : it's a beige sea of bread, breading and potatoes. The new guidelines call for more fruits and vegetables--which the kids have to put on their trays--but (1) fruit is mostly sugar, (2) it's hard to eat certain fruits and veg if you wear braces, (3) fruit and veg aren't filling , and (4) the fruit and veg are going in the trash anyway. Those whole g

My Remarkable Lack of Pain

Falling off a bike, falling on your face, fracturing and spraining an arm, breaking a tooth and knocking two others loose sounds terribly painful. I certainly looked bad afterward: a lot of strangers in stores, on the bus and even on the street saw my black and blue face and arm in a sling and asked me what happened. At the urgent care center; I rated my pain a 4 out of 10 as long as I held my arm still. But 4 out of 10 isn't horrible pain. The bottle of Vicodin I got that day is still in the bag, unopened. My arm wasn't that badly injured--not as bad as my cousin's when she tripped over her dachshund and broke both of her wrists. And my jaw, despite landing on it and still having a bump on my chin, wasn't fractured or broken. Could be I'm a tough old bird--I'm descended from bull riders, homesteaders and blacksmiths. But I think diet has helped. I know that changing my diet to low-carb, taking vitamin D and later adopting the cavity healing diet made my t

Meal Planning Spreadsheet

To make it easy to stay on track with Molly's diet, I've created a meal planning spreadsheet. I've listed the foods and amounts she commonly eats along with calories, carbs, fat, and protein. I just enter how many servings of various foods I'm thinking about feeding her on a given day, and the total nutrients show up. You can download the spreadsheet here: http://www.slideshare.net/lorimiller/nutrient-counter Of course, you can insert rows for other foods if you want to do a little bit of research on nutrient content (like, Nutritiondata.com or copying data from a food package), copy and paste the formulas from the orange (or gray) part of the spreadsheet, and re-do the Total row if needed. Needless to say, you can use this for your own diet if you wish.